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M94A2737.TXT
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1994-10-25
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Document 2737
DOCN M94A2737
TI Comparative study of p24 antigen capture assays in human
immunodeficiency virus-1 (HIV) seropositives.
DT 9412
AU Gotoh M; Matsuda J; Gohchi K; Tsukamoto M; Saitoh N; Department of
Medicine, Teikyo University School of Medicine,; Tokyo, Japan.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):236 (abstract no. PB0373). Unique
Identifier : AIDSLINE ICA10/94369838
AB OBJECTIVE: The detection of p24 antigen has been widely used clinically
employing a commercially available test kit-conventional test (Abott,
USA), but the positivity of p24 in HIV-positive patients has been found
to be relatively low by this method possibly due to the immune complex
formation (p24-anti p24). We compared the sensitivity of the
conventional and new test kit--ICD-PREP Kit (Coulter Corporation, USA)
which enable the immune complex dissociate in conjunction with anti-p24
antibody (ENVCORE, Abott). SUBJECTS: 65 patients with hemophilia,
including 35 infected with HIV and 20 healthy volunteers were studied.
RESULTS: p24 was positive in 6/35 (17%) by conventional test and 16/35
(45%) by ICD-PREP. Four of seven patients (positive for p24 by
conventional test) who were negative for anti-p24 antibody were negative
for p24 by ICD-PREP kit. In contrast, p24 was revealed to be positive
even in patients positive for anti-p24 antibody by the new method. 57%
patients were positive for p24 in overall by two methods. All p24
positive patients were positive for anti-gp41 antibody. CONCLUSION: From
these, we should examine p24 employing both conventional and ICD-PREP
tests to detect p24 antigen precisely.
DE Antigen-Antibody Complex/IMMUNOLOGY AIDS Serodiagnosis/*METHODS
Comparative Study Hemophilia/IMMUNOLOGY Human HIV Core Protein
p24/*BLOOD HIV Seropositivity/*DIAGNOSIS/IMMUNOLOGY HIV-1/*IMMUNOLOGY
Predictive Value of Tests MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).